The Genome Engineering Research Associate will support base editing efforts across cASH species programs by executing experiments, assisting with guide and reagent preparation, and maintaining high-quality documentation. This role requires hands-on experience in genome editing and molecular biology, with a particular interest in base-editing methods (ABE/CBE). The RA will work closely with the Base Editing Manager to carry out established workflows, optimize protocols, and generate high-quality data for downstream applications in species restoration programs.

This position is based on-site in Dallas, TX. Relocation assistance is available.

Duties and Responsibilities:

• Base Editing Experimental Support (60%)

  • Execute base editing experiments (ABE, CBE) under the direction of the Base Editing Manager.
  • Assist with design and preparation of guides, plasmids, and other base-editing components.
  • Perform transfections, cell culture tasks, nucleic acid extractions, and editing outcome assays.
  • Support optimization of workflow parameters to improve editing efficiency and specificity.
  • Help implement new editor variants, delivery strategies, or emerging techniques as directed.

• Data Collection & Documentation (20%)

  • Maintain accurate, timely, and complete records in the Electronic Lab Notebook (ELN).
  • Document protocols, troubleshooting notes, results, and reagent information consistently.
  • Support preparation of summary reports and data packages for internal review.

• Cross-Functional Collaboration (10%)

  • Work closely with genome engineers in GET to ensure coordinated execution of experiments.
  • Provide experimental support for projects involving PRIME editing, large construct engineering, or multimodal editing approaches when needed.
  • Communicate results and progress clearly to the Base Editing Manager and project leads.

• Laboratory Operations Support (10%)

  • Maintain organized reagent inventories, cell line records, and shared equipment relevant to base editing workflows.
  • Assist with ordering materials and preparing common reagents for the team.
  • Participate in routine lab maintenance and compliance with safety standards.

Required Skills and Abilities:

• Hands-on experience with genome editing (CRISPR, ABE/CBE, or similar technologies)
• Proficiency in mammalian cell culture and molecular biology techniques
• Strong attention to detail and commitment to documentation
• Ability to work collaboratively and communicate effectively

Education and Experience:

• Bachelor's or Master’s degree in Molecular Biology, Genetics, Bioengineering, or related field